血清GST-π在非小细胞肺癌诊断中的应用价值

THE CLINICAL VALUE OF SERUM GST-π LEVEL IN DIAGNOSIS OF NON-SMALL CELL LUNG CANCER

目的 :测定肺癌患者血清 GST- π表达 ,探讨其作为非小细胞肺癌肿瘤标志物的临床应用价值。方法 :应用双抗夹心 EL ISA法检测 114例非小细胞肺癌、8例小细胞肺癌、11例肺良性病变及 6 0例健康对照者血清 GST- π含量。结果 :非小细胞肺癌患者血清 GST- π含量、阳性率明显高于健康对照者、小细胞肺癌和良性病变患者 ,血清 GST- π与非小细胞肺癌 TNM分期无关 ,与分化程度有相关性。结论 :血清 GST- π含量可作为非小细胞肺癌的肿瘤标志物 ,血清 GST-

Objective:By measuring the serum GST π level in patients with NSCLC to study the clinical value of it as a tumor marker for patients with NSCLC.Methods:GST π levels in serum of 114 patients with NSCLC,8 patients with SCLC,11 patients with benign lung diseases and 60 healthy subjects were investigated with the sandwich enzyme linked immunosorbent assay(ELISA).Results:The mean serum GST π level and the positive rate were significantly higher in patients with NSCLC than in those with SCLC,benign lung diseases and healthy subjects.No correlation was observed between the GST π level and the TNM staging.The GST π level was related to the degree of differentiation.Conclusion:The serum GST π level may be a valuable tumor marker for NSCLC.It is a useful aid for diagnosis of NSCLC.