磁共振相位对比法电影成像技术在脑脊液测速中的初步研究

Preliminary study of cine phase contrast imaging on CSF flow measurement

目的探讨小角度快速激发扰相位梯度回波序列相位对比法电影成像技术在脑脊液测速中的应用价值。方法采用德国Siemens Avanto 1.5T超导磁共振扫描仪,对16例健康志愿者先行头颅MRI检查,再行(Cine phase contrast,Cine PC)相位对比法电影成像技术结合使用外周的指脉或心电门控等技术并应用Argus软件进行数据测量及分析,在横轴位图像上勾画出ROI(感兴趣区),测量中脑导水管在一个心动周期内脑脊液流动的各动力学参数值。结果 16例健康人的MRI PC幅值图均清晰显示测量区域的解剖结构,定位准确;相位图(phase image)均可判断脑脊液流动的方向、流速的快慢、信号的强弱,并能应用Argus软件进行数据测量及分析。结论相位对比法电影成像技术结合心电同步采集技术,具有成像速度快、突出T1WI加权、电影成像的特点,可以作为脑脊液测速的常规扫描技术。

Objective To investigate the application value of Cine phase contrast （Cine PC） imaging technique with small angle stimulation on spoiled gradient echo. Methods Performed head MRI examinations for 16 healthy volunteers on the 1.5T Siemens Avanto MRI, and then applied Cine PC imaging technique combined with peripheral pulse or ECG trigger. Analyzed the data with the Argus software, and marked the region of interest （ROI） on the transverse axis of the image to measure the kinetic parameters of cerebrospinal fluid （CSF） flow at aqueduct of sylvius in a cardiac cycle. Results All PC amplitude images from the 16 healthy volunteers＇ MR/ examinations displayed the exact localization of anatomical structures at the region measured. The direction, velocity and signal strength of CSF flow could all be estimated and analyzed on the phase images by using the Argus software. Conclusions The Cine PC imaging technique combined with ECG synchronous acquisition could be used as general routine for velocity measurement of CSF flow due to the characteristics of fast and Cine imaging as well as outstanding T1WI.