乙醛脱氢酶2基因rs671多态性和新疆汉族人群原发性高血压的关联性研究

Association between acetaldehyde dehydrogenase 2 gene rs671 polymorphism and essential hypertension in Han population from Xinjiang

目的：探讨乙醛脱氢酶2（ALDH2）基因 rs671多态性在新疆地区汉族人群原发性高血压（EH）发病中的作用。方法应用 Taqman 技术检测了474例汉族 EH 患者和358例正常血压者 ALDH2基因 rs671多态性。结果在男性人群中，饮酒组 rs671的 GA ＋AA 基因型频率和 A 等位基因频率均明显低于不饮酒组（P ＜0．01）；EH 组 rs671的 GA ＋AA 基因型频率和 A 等位基因频率均明显低于对照组（P ＜0．01）。而在女性人群中，EH 组和对照组 rs671的 3 种基因型频率和等位基因频率的分布差异无统计学意义（P ＞0．05）。非条件 Logistic 回归分析校正年龄、体重指数、糖尿病史、饮酒史等影响因素后，在男性人群中 rs671的 GA ＋AA 基因型者患 EH 的风险低于 GG基因型者（OR ＝0．656，95％CI：0．448～0．962，P ＜0．05），GA ＋AA 基因型者收缩压水平明显低于GG 型者（P ＜0．05）。而在男性不饮酒者和女性人群中，GA ＋AA 基因型者和 GG 基因型者血压水平比较差异无统计学意义。结论ALDH2基因 rs671多态性可能和新疆汉族男性人群 EH 的发生相关，rs671的 GA ＋AA 基因型可能是汉族男性人群 EH 的一个保护因素。

Objective To investigate the relationship between acetaldehyde dehydrogenase （ALDH）2 gene rs671 polymorphism and essential hypertension in a Han population in Xinjiang.Methods Taqman assay was performed to screen the polymorphism of ALDH2 gene rs671 in 474 EH patients and 358 normotensives.Results In males,the frequency of GA ＋AA genotype and A allele of rs671 was significant-ly lower in drinkers than that in non-drinkers（all P 〈0.01）.Among males,the frequency of GA ＋AA geno-type and A allele of rs671 was significantly lower in patients with EH than in controls（P 〈0.01）.Among females,there was no significant difference in the distribution of genotypes and allele of rs671 between EH group and controls group（P 〉0.05）.Logistic regression analysis adjusted for confounding factors inclu-ding drinking for men showed that carriers of GA ＋AA genotype had an decreased risk of EH,compared to GG genotype（OR =0.656,95%CI：0.448-0.962,P 〈0.05）.In male drinkers,the systolic blood pressure was significantly lower in subjects with GA ＋AA genotype than those with GG genotype （P 〈0.05）.But this association was not observed in male non-drinkers and females.Conclusion For Han males,ALDH2 gene rs671 polymorphism was associated with the development of EH,while GA ＋AA genotype might be an influencing protective factor on EH.