糖尿病合并非酒精性脂肪肝的危险因素分析

Risk factor analysis of type 2 diabetes mellitus with non-alcoholic fatty liver disease

目的：探讨2型糖尿病合并非酒精性脂肪肝（NAFLD）的危险因素。方法：回顾性分析104例2型糖尿病合并NAFLD患者和157例未合并NAFLD糖尿病患者性别、年龄、糖尿病家族史、高血压病史、吸烟史、体重指数（BMI）、血尿酸、谷丙转氨酶、谷草转氨酶、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、超敏C反应蛋白、血浆凝血酶原时间（PT）、糖化血红蛋白（HBA1C）、空腹血糖（FPG）的差异。非条件logistic回归模型进行2型糖尿病合并NAFLD的危险因素分析。结果：2组年龄、BMI、HBA1C、FPG、TG差异有统计学意义（χ2=7.266、66.897、8.911、9.348、30.161,P〈0.05）;Logistic回归模型分析结果显示肥胖、高TG是2型糖尿病合并NAFLD的危险因素[OR（95%CI）=4.503（2.930~6.919）,1.563（1.154~2.117）]。结论：肥胖和高TG是2型糖尿病合并NAFLD的危险因素。

Aim： To investigate the risk factors of type 2 diabetes mellitus with non-alcoholic fatty liver disease （ NAFLD） .Methods：A total of 261 cases of type 2 mellitus diabetes were collected and allocated into 2 groups according to with or without NAFLD .The risk factors of type 2 mellitus diabetes with NAFLD were analyzed by using logistic regres-sion analysis.Results：The analysis of univariate factor showed that age ,BMI,HBA1C,FPG,TG had statistical significance between the 2 groups（χ2 =7.266,66.897,8.911,9.348,30.161,P〈0.05）.Logistic regression analysis demonstrated that obesity and increased TG are dangerous factors of type 2 diabetes mellitus with NAFLD[OR（95%CI） =4.503 （2.930-6.919）,1.563（1.154-2.117）].Conclusion：Obesity and high level of TG are dangerous factor of type 2 dia-betes mellitus with NAFLD .