健脾清肠汤对溃疡性结肠炎肠黏膜屏障及免疫功能的影响

Study on the Effect of Decoction for Invigorating Spleen Bowel Intestinal Mucous Colitis Barrier and Immune Function of Ulcer

目的探讨健脾清肠汤对溃疡性结肠炎肠黏膜屏障及免疫功能的影响。方法收集我院接诊的100例溃疡性结肠炎患者资料,将患者随机分为观察组和对照组,各50例。观察组患者采用健脾清肠汤治疗,对照组患者采用柳氮磺胺嘧啶及诺氟沙星胶囊治疗。比较两组患者肠黏膜屏障情况与治疗前后的免疫球蛋白G(Ig G)与补体C3。结果治疗后,观察组与对照组患者的肠黏膜屏障未痊愈率分别为16.0%、38.0%;观察组患者的Ig G与补体C3均高于对照组,差异均有统计学意义(均P<0.05)。结论健脾清肠汤治疗溃疡性结肠炎能有效促进肠黏膜屏障痊愈,并能提高患者的免疫功能。

Objective To investigate the influence of the spleen soup ulcerative colitis bowel intestinal barrier and immune function.Methods We col ection 100 cases of ulcerative colitis patients in our hospital admissions,were randomly divided into observation group and control group,each of 50 cases.The observation group with spleen Qingchang soup treatment,the control group using sulfasalazine and Norfloxacin Capsules treatment.Before and after treatment were compared between the two groups of barrier and intestinal mucosa in patients with immunoglobulin G（IgG）and complement C3.Results After treatment,the observation group and the control group of patients without intestinal mucosal barrier recovery rate were 16.0%,38.0%;observation of IgG and complement C3 group patients were higher than those of the control group,the difference was statistical y significant（P〈0.05）.Conclusion Spleen bowel Decoction in the treatment of ulcerative colitis can effectively promote the intestinal mucosal barrier recovery, and can improve the immune function of patients.