摘要
免疫球蛋白G4（IgG4）相关性疾病是近几年新发现和确定的一种复合性免疫系统疾病，其特征为血清IgG4水平升高、受累组织IgG4阳性浆细胞浸润。该病累及范围广，包括泪腺、唾液腺、肺、胰腺、肝脏、胆管、肾脏、前列腺和后腹膜等，临床表现为同时或不同时间各脏器肿大、结节或肥厚。全面、准确地诊断有利于该病的早期治疗和预后改善。18F-FDG PET/CT显像在IgG4相关性疾病中的诊断、疗效评估与随访监测等方面具有重要作用。笔者将对18F-FDG PET/CT在IgG4相关性疾病中的应用及研究进展进行综述。
As a newly identified systemic syndrome characterized by a high level of serum immunoglobulin G4 （ IgG4 ） and dense infiltration of IgG4-positive plasma cells into multiple organs including lacrimal gland, salivary gland, lung, pancreas, liver, biliary duct, kidney, prostate, retroperitoneum and so on, IgG4-related disease（IgG4-RD）has attracted growing attention recently. Timely and accurate diagnosis is an essential prerequisite for early intervention leading to better recovery and outcome in patients with IgG4-RD. 18F-FDG PET/CT has been served as an important imaging tool for patients with IgG4-RD in assessing organ involvement, guiding biopsy and monitoring therapeutic response. This review will summarize the state-of-the-art on applications of 18F-FDG PET/CT in patients with IgG4-RD.
出处
《国际放射医学核医学杂志》
2015年第1期55-60,共6页
International Journal of Radiation Medicine and Nuclear Medicine
基金
国家自然科学基金（81271600）
湖北省科技计划（2011CDB551）
华中科技大学同济医学院附属同济医院临床新技术、新业务基金（2010026）
