阿莫罗芬搽剂联合口服伊曲康唑与特比萘芬治疗甲真菌病临床观察

Amorolfine Liniment Combined with Oral Itraconazole and Terbinafine in Treatment of Onychomycosis

目的:观察阿莫罗芬搽剂联合口服伊曲康唑与特比萘芬治疗甲真菌病的临床效果。方法:选取2014年1月至2014年8月46例甲真菌病患者,随机分为两组,每组23例。对照组给予阿莫罗芬搽剂治疗,实验组在对照组的基础上给予口服伊曲康唑与特比萘芬治疗,对比两组临床疗效。结果:实验组患者的治疗总有效率高达95.7%,比对照组的78.3%更高(P<0.05);实验组真菌学疗效明显优于对照组(P<0.05)。结论:临床采用抗真菌药联合口服治疗甲真菌病可有效杀灭或抑制真菌,有利于巩固疗效、促进患者恢复,应予以推广应用。

Objective： To observe clinical effect of amorolfine liniment combined with oral itraconazole and terbinafine in treatment of onychomycosis. Method： 46 cases of patients with onychomycosis from Jan.2014 to Aug. 2014 in our hospital were randomly divided into two groups,23 cases in each group.The control group were given amorolfine liniment,the experimental group were given itraconazole and terbinafine oral treatment on the basis of control group. Treatment effects of the two groups were observed and statistically analyzed. Result： The total effective rate of experimental group was 95.7%,which was significantly higher than the control group 78.3%（ P〈0.05）; The experimental group mycological efficacy was significantly better than the control group（ P〈0.05）. Conclusion： The clinical use of combined oral antifungal treatment of onychomycosis can effectively kill or inhibit fungi,conducive to the consolidation effect,promote the recovery of patients,should be promoted and used.