激素冲击治疗重症结缔组织病患者并发类固醇糖尿病的影响因素分析

Analysis on the impact factors of hormone impact treatment for severe connective tissue disease complicated with steroid diabetes

目的探讨激素冲击治疗重症结缔组织病患者并发类固醇糖尿病的因素。方法选取本院2012年4月-2014年3月收治的55例重症结缔组织病患者为研究对象,均给予激素冲击疗法。根据用药后并发症发生情况分为A、B两组,回顾性分析其临床资料,分析治疗后并发类固醇糖尿病的相关危险因素。结果两组患者的性别、病程等指标差异无统计学意义（P〉0.05）;年龄、体重指数、C-反应蛋白水平及激素用量是治疗后并发类固醇糖尿的独立危险因素。结论高龄、高激素用量及体重指数与C-反应蛋白偏高的患者,应用激素冲击疗法后应需给予实时体征监测及相关防预措施,以此降低治疗后并发类固醇糖尿病的风险。

Objective To explore the impact factors of hormone therapy for severe connective tissue disease complicated with steroid diabetes. Methods 55 patients with severe connective tissue in our hospital from April 2012 to March2014 were chosen as research objects,all were treated with glucocorticoid pulse therapy,and were divided into group A and group B according to the complications after treatment.The clinical data was retrospectively analyzed,the related risk factors of concurrent steroid diabetes after treatment was analyzed. Results The difference of gender,course of disease and other indexes between the two groups was not significant（P〉0.05）;The age,body mass index,level of C-reactive protein and the amount of hormone was the independent risk factor of the patient with steroid diabetes. Conclusion Patient with elder,high dosage of hormones and body mass index and C-reactive protein should take real-time vital signs monitoring and related preventive measures after glucocorticoid pulse therapy in order to reduce the risk of diabetes complicated with steroid treatment.