江苏省部分地区HIV/AIDSCD4^+T淋巴细胞计数检测结果

Analysis of CD4^+T lymphocyte counts of HIV-infected and AIDS patients in some regions of Jiangsu Province

目的了解不同传播途径和发现时间对HIV感染者和AIDS患者CD4+T淋巴细胞水平的影响。方法通过流式细胞绝对计数法,对江苏省部分地区HIV感染者和AIDS患者CD4+T淋巴细胞水平进行检测,采用SPSS 16.0软件进行正态性检验和非参数检验分析。结果 212例HIV感染者中,CD4+T淋巴细胞计数中位数为371.50(271.25,517.75)/μL;527例AIDS患者中,治疗前中位数为165.00(68.00,229.00)/μL;治疗后中位数为278.00(176.00,386.00)/μL;治疗前后差异有统计学意义(Z=-7.171,P<0.05)。不同发现时间AIDS患者治疗前CD4+T淋巴细胞绝对计数差异无统计学意义(χ2=2.52,P>0.05),治疗后CD4+T淋巴细胞计数差异有统计学意义(χ2=43.41,P<0.05);不同发现时间HIV感染者CD4+T细胞计数差异无统计学意义(χ2=6.77,P>0.05)。不同传播途径AIDS患者CD4+T淋巴细胞绝对计数差异无统计学意义(χ2=7.65,P>0.05);HIV感染者中经同性传播感染者CD4+T淋巴细胞计数高于经异性传播感染者,差异有统计学意义(χ2=8.18,P<0.05)。结论应加强AIDS抗病毒治疗者的免疫学监测,及对同性传播人群的关注和有效干预,提高抗病毒治疗效果。

Objective To analyze impact of different transmission routes and discovery time points on CD4＋T lymphocyte levels of HIV-infected and AIDS patients.Methods Flow cytometry was used to measure absolute counts of CD4＋T lymphocyte of HIV-infected and AIDS patients.Data were analyzed by SPSS 16.0software using Kolmogorov-Smirnov Test and nonparametric tests.Results Median of CD4＋T lymphocyte count was 371.50（271.25,517.75）/μL among 212HIV-infected patients.For 527 AIDS patients,median of CD4＋T lymphocyte counts before/after treatment were 165.00（68.00,229.00）/μL and 278.00（176.00,386.00）/μL,respectively,with significant difference（Z=-7.171,P〈0.05）.For AIDS patients discovered at different time points,absolute CD4＋T lymphocyte counts showed no significant difference before treatment（χ2=2.52,P〉0.05）,however,absolute CD4＋T lymphocyte counts showed significant difference after treatment（χ2=43.41,P〈0.05）.Absolute CD4＋T lymphocyte counts for HIV-infected patients discovered at different time points showed no significant difference（χ2=6.77,P〉0.05）.Absolute CD4＋T lymphocyte counts for AIDS patients transmitted via different routes showed no significant difference（χ2=7.65,P〉0.05）.For HIV-infected patients,absolute CD4＋T lymphocyte count of patients transmitted via homosexual route was higher than that of patients transmitted via heterosexual route,with significant difference（χ2=8.18,P〈0.05）.Conclusion In order to improve antiviral therapeutic effect,immunological surveillance for patients should be strengthened,more attention and effective intervention measures should be taken for homosexual population.