异腈参与的惰性键活化反应研究进展

Recent Advances in Inert Bonds Activation with Isocyanides

近年来,过渡金属催化的C—H键官能团化反应引起了广泛的关注并得到迅速发展.作为一个不可替代的合成子,异腈已被广泛应用于合成各类含氮杂环化合物.本综述介绍了异腈参与的惰性键活化反应的最新研究进展及其在有机合成中的应用,包括异腈对C—H键或N—H键的插入反应以及异腈参与的自由基氧化成环反应等.

Transition-metal-catalyzed C—H functionalization has attracted tremendous interest as a valuable tool for the construction of heterocycles. As a unique building block, isocyanides have been widely used in the synthesis of various nitrogen-containing heterocycles through multi-component Passerini and Ugi reactions. This review highlights the recent progress in inert bonds activation with isocyanides, including C—H bond or N—H bond insertion of isocyanides and radical oxidative annulation of isocyanides.