一种N,N-二甲基乙酰胺提供亚甲基在水相中构建亚甲基双酰胺的方法

Construction of Methylenebisamides in Aqueous Phase Using N,N-Dimethylacetamide to Provide Methylene

双酰胺的结构在合成仿肽类化合物中具有十分重要的作用.以酰胺为底物,N,N-二甲基乙酰胺(DMAC)提供亚甲基,Na2S2O8为氧化剂,NH4)2Ce(NO3)6为催化剂,在水相中反应合成亚甲基双酰胺化合物.采用1H NMR,13C NMR和LRMS对目标产物进行了表征.研究表明该方法具有环境友好,后处理操作简单和产率高等优点,为亚甲基双酰胺化合物提供了新的方法.

A variety of bisamides which are key fragments in the formation of peptidomimetic compounds were synthesized. An effective method to synthesize methylenebisamides is by the reaction of amides with N,N-dimethylacetamide（DMAC）using Na2S2O8 as the oxidant and（NH4）2Ce（NO3）6 as the catalyst in water. The structures of product were confirmed by 1H NMR, 13 C NMR and LRMS. The methodology will provide new strategies for the synthesis of methylenebisamides, which has the advantage of environment-friendly, simple workup and high yield.