奥沙利铂不同静脉输注途径的不良反应对比分析

Contrast analysis of oxaliplatin adverse reactions though different intravenous injection ways

目的：比较奥沙利铂经3种不同静脉途径输注致毒副反应发生率及程度，探讨其最适宜的输注方式。方法选择奥沙利铂为主化疗的胃肠道肿瘤患者90例，采用随机数余数分组法分为3组，每组30例，分别通过外周静脉、深静脉穿刺置入中心静脉导管（ CVC）及经外周静脉穿刺中心静脉置管（ PICC）输注奥沙利铂，比较不同静脉途径输注患者周围神经、血液系统、消化系统毒副反应的发生率及程度。结果外周静脉组、CVC组、PICC组患者周围神经炎发生率分别为37．50％，21．43％，10．00％，差异有统计学意义（χ2＝6．628，P＜0．05）；血液系统毒副反应发生率分别为53．13％，53．57％，50．00％，消化系统毒副反应分别为78．13％，92，86％，73．33％，差异均无统计学意义（χ2值分别为0．090，3．892；P＞0．05）。结论奥沙利铂静脉输入首选PICC，其次CVC，避免使用外周静脉输注。

Objective To compare the adverse reaction′s incidence of oxaliplatin with three different injection ways , to explore the most appropriate infusion .Methods A total of 90 patients were randomly divided into 3 groups averagely： peripheral vein （ PV ） group, central venous catheterization （ CVC ） group and peripherally inserted central catheter （ PICC） group.The occurrence rate and degree of adverse reaction were compared among groups including peripheral neuritis , blood system , digestive system toxicity .Results The occurrence rates of peripheral neuritis were 37.50%, 21.43%, 10.00% in the PV group, CVC group and PICC group, and the difference was statistically significant （χ2 =6.628,P0.05）.Conclusions The best method of oxaliplatin infusion among these three ways is PICC, followed by CVC, and PV is not recommended.