3-二甲氨基苯酚的合成
Synthesis of 3-Dimethylaminophenol
摘要
以间氨基苯甲醚为起始原料,经过N-二甲基化反应,O-脱甲基化反应,合成得到重要的医药、染料中间体3-二甲氨基苯酚,经过工艺优化,收率达到80.0%,并得到了适宜于工业化的合成路线。
3-Dimethylaminophenol was prepared from m-aminoanisole by N-methylation and O-demethylation reaction in total yield of 80.0%.
出处
《浙江化工》
CAS
2015年第3期41-43,共3页
Zhejiang Chemical Industry
参考文献8
-
1Yanagisawa,Shinken.m-Hydroxyphenyltrimethylammonium bromide dimethylcarbamate:JP,26003071[P].1951-6-13.
-
2Mc Nall F J.The assay of prostigmine[J].Journal of the Association of Official Agricultural Chemists,1942,25:814-816.
-
3Sasho Setsuya,Obase Hiroyuki,Ichikawa Shunji,et al.Synthesis of 2-imidazolidinylidene propanedinitrile derivatives as stimulators of gastrointestinal motility[J].Journal of Medicinal Chemistry,1993,36(5):572-579.
-
4Ge Xin,Pan Jiong-bin,Qian Chao,et al.Mechanism study on Raney nickel-cat alyzed amination of resorcinol[J].Catalysis Communications,2014,46:201-207.
-
5贺承相,房永民,段德利,等.3-(N,N-二甲氨基)苯酚的制备方法:CN,102381993[P].2012-3-21.
-
6Grove S J A,Kaur J,Muir A W,et al.Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block[J].Bioorganic&Medicinal Chemistry Letters,2002,12(2):193-196.
-
7Brooks Paige R,Wirtz Michael C,Vetelino Michael G,et al.Boron trichloride/tetra-n-butylammonium iodide:a mild,selective combination reagent for the cleavage of primary alkyl aryl ethers[J].Journal of Organic Chemistry,1999,64(26):9719-9721.
-
8Shivarkar Anandkumar B,Gupte Sunil P,Chaudhari Raghunath V.Tandem synthesis ofβ-amino alcohols from aniline,dialkyl carbonate,and ethylene glycol[J].Industrial&Engineering Chemistry Research,2008,47(8):2484-2494.
-
1马玉贞,王维剑.依酚氯铵注射液中有关物质的HPLC法测定[J].中国医药工业杂志,2014,45(9):871-873.
-
2袁加程,刘长春.离子液体中6-羟基-3,4-二氢-2(1H)-喹啉酮的合成[J].精细化工,2014,31(5):603-606. 被引量：3
-
3葛海霞,王礼琛,余潜.7-羟基-3,4-二氢-2(1H)-喹啉酮的合成及两个副产物的分离确证[J].中国现代应用药学,2005,22(5):390-392. 被引量：4
