表观遗传调控在胎源性精神疾病中的研究进展

Progress of research on epigenetic modifications in fetal original mental diseases

宫内不良环境可导致胎儿某些分子、组织结构发生永久性改变即编程效应,使其成年后对内外环境变化的反应性产生异常,进而导致其患某些疾病的风险增加,而这其中的机制尚未阐明。近年来研究发现,表观遗传修饰如DNA甲基化、组蛋白乙酰化、micro RNA转录调节等可能是产生编程效应的重要机制之一。本文就表观遗传学机制在胎源性精神疾病中的研究进展进行综述,以期待对部分胎儿起源的成年疾病发生、治疗带来新的启示。

Programming effect means that the adverse intrauterine factors could lead to a permanent change in molecules or tissue structures. When the individuals grow up, this effect may affect the reaction to their environment which further increased susceptibility of adult diseases. The mechanism has not been clearly illustrated by now. Recently, studies revealed that epigenetics, such as DNA methylation, histone acetylation and micro RNA transcriptional modification may be important mechanisms for programming effect. In this review, this paper discuss the epigenetics in the development of fetal origins mental disease, hoping to discover some new revelation in some fetal origins of adult disease.