期刊文献+

超声斑块稳定性、颈总动脉内中膜厚度和血清C-反应蛋白与脑梗死相关 被引量:2

Relationship among Ultrasound Plaque Stability,Intima - medial Thickness,Serum C - reaction Protein and Cerebral Infarction
原文传递
导出
摘要 目的:观察脑梗死患者颈动脉超声斑块稳定性、颈总动脉内中膜厚度(IMT)和血清 C -反应蛋白(CRP)水平,阐明它们与脑梗死发生的关系。方法选取我院神经内科收治的脑梗死连续性患者112例作为实验组,同期体检中心的连续性健康体检者93例作为对照组,观察并评估颈动脉斑块的稳定性,测量颈动脉血管内中膜厚度(IMT)、血清 CRP 水平及其相关性。结果①实验组的斑块发生率76.8%(86例),IMT (1.24±0.31)mm,血清 CRP(5.57±2.43)mg/ L,对照组的斑块发生率16.1%(15例),IMT(0.59±0.06)mm,血清 CRP(2.14±0.85)mg/ L,实验组三项指标均高于对照组,有统计学意义(P ﹤0.05);②在86例实验组斑块患者中,稳定斑块者19例(22.1%),不稳定斑块者67例(77.9%),脑梗死患者中不稳定性斑块的发生率比稳定性斑块高,差异有统计学意义(P ﹤0.05);③稳定斑块组患者的 IMT 为(0.87±0.11)mm,血清 CRP 为(4.45±1.82)mg/ L,不稳定斑块组患者的 IMT 为(1.21±0.29)mm,血清 CRP 为(8.03±2.77)mg/ L,后者的CRP 水平和 IMT 值均明显高于前者( P ﹤0.05);④实验组 CRP 水平和 IMT 呈正相关,相关系数 r =0.73,有统计学意义(P ﹤0.05),对照组 CRP 水平和 IMT 呈正相关,相关系数 r =0.67,有统计学意义(P ﹤0.05),两组混合后 CRP 水平和 IMT 呈正相关,相关系数 r =0.69,有统计学意义(P ﹤0.05)。结论①脑梗死患者的颈动脉斑块发生率高于健康人群;②在有斑块的脑梗死患者中,不稳定性斑块发生率显著高于稳定性斑块;③不稳定斑块患者的 IMT 和 CRP 显著高于稳定性斑块患者。结果提示颈动脉斑块的不稳定性、IMT 增厚和 CRP 升高均与脑梗死的发生相关,对脑梗死的预测可能具有重要意义。 Objective To investigate the relationship among carotid plaque stability,intima - medial thickness (IMT),serum C - reaction protein(CRP)and cerebral infarction. Methods 112 hospitalized patients with cerebral infarction were taken as group I,while 93 healthy cases as group II. Carotid plaque stability,IMT and CRP were meas-ured and evaluated. Results ①Incidence of plaque was 76. 8% with IMT(1. 24 ± 0. 31)mm and serum CRP(2. 14 ± 0. 85)mg/ L in group I. Incidence of plaque,IMT and CRP were 16. 1% ,(0. 59 ± 0. 06)mm and(2. 14 ± 0. 85) mg/ L respectively in group II. There were significant differences between the two groups(P ﹤ 0. 05). ②There were 19 patients with stable plaque(22. 1% )in 86 patients in group I. The incidence of unstable plaque was significantly high-er than stable plaque in patients with cerebral infarction(P ﹤ 0. 05). ③IMT was(0. 87 ± 0. 11)mm with CRP(4. 45 ± 1. 82)mg/ L in for patients with stable plaque. IMT was(1. 21 ± 0. 29)mm with CRP(8. 03 ± 2. 77)mg/ L in patients with unstable plaque(P ﹤ 0. 05). ④CRP was positively correlated with IMT in group I(r = 0. 73,P ﹤ 0. 05). CRP was positively correlated with IMT in group II(r = 0. 67,P ﹤ 0. 05). The total CRP was positively correlated with total IMT (r = 0. 69,P ﹤ 0. 05). Conclusion ①The incidence of carotid plaque is higher in patients with cerebral infarction.②The incidence of unstable plaque is significantly higher than stable plaque in patients with cerebral infarction. ③IMT and CRP are higher in patients with unstable plaque. There are relationships among carotid plaque stability,IMT, CRP and cerebral infarction,which may have predictive significance for cerebral infarction.
出处 《医学新知》 CAS 2015年第1期36-37,41,共3页 New Medicine
关键词 脑梗死 动脉粥样硬化 颈动脉斑块 超声波 C 反应蛋白 Cerebral infarction Atherosclerosis Carotid plaque Ultrasound C - reaction protein
  • 相关文献

参考文献12

二级参考文献57

  • 1张子曙,刘军,谭长连,李亚军.颈动脉狭窄的CTA与DSA对照研究[J].中国医学计算机成像杂志,2004,10(3):149-154. 被引量:22
  • 2柳标,赵宝珍,姥义,陈晓宇.经颅彩色多普勒超声对颈内动脉闭塞患者颅内侧支循环及血供的研究[J].中华超声影像学杂志,2006,15(4):289-292. 被引量:16
  • 3张晓莉,郑素萍,杨志伟,张暹东,陈建波.常规MRI与磁共振弥散加权成像定量化评估急性脑梗死发病:与CT及常规MRI的成本效果比[J].中国临床康复,2006,10(24):42-44. 被引量:17
  • 4Li CJ,Sun HW,Zhu FL,et al.Local adiponectin treatment reduces atherosclerotic plaque size in rabbits[J].J Endocrinol,2007,193(1):137-145.
  • 5Okamoto Y,Arita Y,Nishida M,et al.An adipocyte-derived plasma protein,adiponectin,adheres to injured vascular walls[J].Horm Metab Res,2000,32(2):47-50.
  • 6Yokota T,Oritani K,Takahashi I,et al.Adiponectin,a new member of the family of soluble defense collagens,negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages[J].Blood,2000,96(5):1723-1732.
  • 7Ouchi N,Kihara S,Funahashi T,et al.Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue[J].Circulation,2003,107(5):671-674.
  • 8Ouchi N,Kihara S,Arita Y,et al.Adiponectin,an adipocyte-derived plasma protein,inhibits endothelial NF-kappa B signaling through a cAMP-dependent pathway[J].Circulation,2000,102(11):1296-1301.
  • 9中国高血压防治指南修订委员会.中国高血压防治指南(2005年修订版)[J].高血压杂志,2005,.
  • 10Eva Bartels原著.华扬,郑宇,主译.脑血管彩色多普勒超声图谱及手册.北京:中国医药科技出版社,2010:154-155.

共引文献119

同被引文献18

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部