TAZ和KLF5在肝细胞癌组织中的表达及其临床意义

Evaluation of TAZ and KLF5 expression and their clinical significance in hepatocellular carcinoma

目的:检测TAZ和KLF5在肝细胞癌(HCC)及对应癌旁组织中的表达情况,分析两者的临床意义。方法:收集76例HCC及对应癌旁组织,运用免疫组化技术检测TAZ及KLF5的表达情况,分析两者与HCC临床病理特征之间的相关性。结果:TAZ及KLF5蛋白在HCC组织中的表达显著高于对应癌旁组织(P=0.001;P=0.035);TAZ及KLF5蛋白表达与肿瘤病理分级(P=0.007;P=0.047)和TNM分期(P=0.009;P=0.040)显著相关;HCC组织中TAZ与KLF5蛋白表达显著正相关(r=0.651,P=0.003)。结论:HCC组织中TAZ及KLF5过表达与恶性临床病理参数相关,且TAZ与KLF5蛋白表达正相关,提示TAZ可能通过抑制KLF5蛋白降解促进HCC进展。

Objective： To investigate the expression of TAZ and KLF5 and their clinical significance in hepatocellular carcinoma （HCC）. Methods ：We freshly collected 76 samples of surgically resected HCC and matched normal tumor-adjacent tissues and detected TAZ and KLF5 expression in these samples using immunohistochemical staining. The clinical significance of TAZ and KLF5 protein expression were analysed. Results：The protein expression of TAZ and KLF5 in HCC tissues was significantly higher than those in matched normal tumor-adjacent tissues （ P = O. 001 ; P = 0. 035 ）. Clinicopathological analysis suggested that TAZ and KLF5 protein expression were associated with histopathological differentiation （ P = O. 007 ; P = O. 047 ） and TNM stage （ P = 0. 009 ; P = 0. 040）. TAZ was positively correlated with KLF5 protein in HCC tissues （r = 0. 651, P = O. 003 ）. Conclusion：The high-expression of TAZ and KLF5 are correlated with poor clinicopathological characteristics, and TAZ is positively associated with KLF5 in HCC tissues, suggesting that TAZ may promote tumor progression through inhibition of KLF5 protein degradation in HCC.