润肤保湿乳膏治疗血虚风燥型银屑病

Skin Moisturizing Cream for blood deficiency and wind-dryness type of psoriasis

目的观察润肤保湿乳膏治疗血虚风燥型银屑病的临床疗效及其对皮肤屏障功能的影响。方法将60例患者随机分为润肤保湿乳膏(薏苡仁、人参、当归、核桃、桃仁、红花、甘草等)治疗组30例和尿素乳膏对照组30例。各外涂8周,3次/d,观察治疗前后的主要临床症状及PASI积分情况;采用Soft 5.5测定仪对30例银屑病患者用药前、中、后及20例健康人皮肤屏障功能指标包括油脂水平、水分含量及p H值进行测定,并观察润肤保湿乳膏治疗前、中、后患者及健康人皮肤屏障功能指标的差异。结果治疗组与对照组总有效率分别为93.3%和70.0%,经统计学处理,差异有统计学意义(P<0.05)。润肤保湿乳膏治疗后血虚风燥型银屑病的红斑、丘疹、鳞屑等主要临床症状积分及PASI积分较治疗前明显降低(P<0.05),其中以鳞屑最为显著(P<0.01),作用优于对照组(P<0.05)。2组均未见不良反应。30例银屑病患者治疗后皮肤表面油脂及水分含量明显提高(P<0.05),p H值(P<0.01)明显降低,但仍未达到健康人水平。结论润肤保湿乳膏明显改善血虚风燥银屑病患者的主要临床症状,尤以鳞屑为主,且有利于银屑病患者皮肤屏障功能恢复。

Objective To observe the effect of Skin Moisturizing Cream on blood deficiency and wind-dryness type of psoriasis and its skin barrier function. Methods The 60 cases were randomly divided into the Skin Moisturizing Cream （coix seed, ginseng, Chinese angelica, walnut, peach kernel, safflower, licorice, etc. ） as the experimental group, 30 cases. And the Urea Cream control group , 30 cases. They were treated for 8 weeks and 3 times a day. Main clinical symptoms and PASI score were observed before and after treatment; SoftS. 5 tester was used to test the skin barrier function index including lipid levels, moisture content and pH value in 30 patients with psoriasis before, during and after the treatment and 20 healthy cas- es. The differences of the skin barrier function between Skin Moisturizing Cream group before, during, after treatment and the healthy group were observed. Results The total effective rates of treatment group and control group were 93.3 % and 70.0 %. After statistical processing, there are statistical significance （ P 〈 0.05）. The major clinical symptoms of erythema, papules, scales and PASI score of Skin Moisturizing Cream after treatment were significantly lower than those of pre-treatment （ P 〈 0.05）, especially the scales （ P 〈 0.01 ）, which is better than that of control group （ P 〈 0.05）. There were no ad-verse reactions in the two groups. The skin surface grease and moisture content of 30 patients with psoriasis increased significantly （P 〈 0.05） and pH （P 〈 0.01 ） significantly decreased after treatment, but they did not reach the level of healthy people. Conclusion Skin Moisturizing Cream can obviously improve the main clinical symptoms of the blood deficiency and wind-dryness type of psoriasis patients, especially the scale. It＇s beneficial to recover the skin barrier function of patients with psoriasis.