摘要
实验表明,阿苯哒唑200mg×3/d×6是囊虫的致死量。囊尾蚴受到药物作用后,最早的病变是神经索及石灰颗粒的形成受损。进而为皮层内质网的肿胀、线粒体的凝固、基质混浊,肌纤维变形,出现突起。致死性病变为皮层及实质区的广泛性溶解坏死,内部结构不能分辨。200mg/d×6组,作用轻微;200mg×2/d×6组,虽虫体有破坏,但尚不致死。
Cysticercosis patients were treated with three therapeutic groups of albendazole,i.e.200mg/d×6; 200mg×2/d×6;The 200mg×3/d×6.The subcutaneous bladder worms were removed and observed by TEM at 7th,14th and 28th day respectively after the treatment.The 200mg/d×6 group was less effective. However,damage to the nerve cord of the worm occurred,but it tended to be repaired at 28th day.In the 200mgx×2/d×6 group,some pathologieal changes occurred but at the 28th day after treatment the change was not aggravating,the 200mg×3/d×6 was the lethal dose.Serious patholgieal changes in the worm were observed,Necrosis was noticed at the tegument and parenchyma area.
出处
《中国寄生虫病防治杂志》
CSCD
1991年第3期193-194,共2页
Chinese Journal of Parasitic Disease Control
