摘要
Collagenous gastritis is a rare disease characterized by the subepithelial deposition of collagen bands thicker than 10 μm and the infiltration of inflammatory mononuclear cells in the lamina propria. Collagenous colitis and collagenous sprue have similar histological characteristics to collagenous gastritis and are thought to be part of the same disease entity. However, while collagenous colitis has become more common in the field of gastroenterology, presenting with clinical symptoms of chronic diarrhea in older patients,collagenous gastritis is rare. Since the disease was first reported in 1989, only 60 cases have been documented in the English literature. No safe and effective treatments have been identified from randomized, controlled trials. Therefore, better understanding of the disease and the reporting of more cases will help to establish diagnostic criteria and to develop therapeutic strategies. Therefore, here we review the clinical characteristics, endoscopic and histological findings, treatment, and clinical outcomes from case reports and case series published to date, and provide a summary of the latest information on the disease. This information will contribute to improved knowledge of collagenous gastritis so physicians can recognize and correctly diagnose the disease, and will help to develop a standard therapeutic strategy for future clinical trials.
Collagenous gastritis is a rare disease characterizedby the subepithelial deposition of collagen bandsthicker than 10 μm and the infiltration of inflammatorymononuclear cells in the lamina propria. Collagenouscolitis and collagenous sprue have similar histologicalcharacteristics to collagenous gastritis and are thoughtto be part of the same disease entity. However, whilecollagenous colitis has become more common inthe field of gastroenterology, presenting with clinicalsymptoms of chronic diarrhea in older patients,collagenous gastritis is rare. Since the disease was firstreported in 1989, only 60 cases have been documentedin the English literature. No safe and effective treatmentshave been identified from randomized, controlled trials.Therefore, better understanding of the disease and thereporting of more cases will help to establish diagnosticcriteria and to develop therapeutic strategies. Therefore,here we review the clinical characteristics, endoscopicand histological findings, treatment, and clinical outcomesfrom case reports and case series published to date,and provide a summary of the latest information on thedisease. This information will contribute to improvedknowledge of collagenous gastritis so physicians canrecognize and correctly diagnose the disease, and willhelp to develop a standard therapeutic strategy forfuture clinical trials.
