摘要
The pH of body fluids is one the most important keyfactors regulating various cell function such as enzyme activity and protein-protein interaction via modification of its binding affinity. Therefore, to keep cell function normal, the pH of body fluids is maintained constant by various systems. Insulin resistance is one of the most important, serious factors making the body condition worse in diabetes mellitus. I have recently found that the pH of body(interstitial) fluids is lower in diabetes mellitus than that in non-diabetic control, and that the lowered pH is one of the causes producing insulin resistance. In this review article, I introduce importance of body(interstitial) fluid pH in regulation of body function, evidence on abnormal regulation of body fluid pH in diabetes mellitus, and relationship between the body fluid pH and insulin resistance. Further, this review proposes perspective therapies on the basis of regulation of body fluid pH including propolis(honeybee product) diet.
The pH of body fluids is one the most important keyfactors regulating various cell function such as enzymeactivity and protein-protein interaction via modificationof its binding affinity. Therefore, to keep cell functionnormal, the pH of body fluids is maintained constant byvarious systems. Insulin resistance is one of the mostimportant, serious factors making the body conditionworse in diabetes mellitus. I have recently found thatthe pH of body （interstitial） fluids is lower in diabetesmellitus than that in non-diabetic control, and thatthe lowered pH is one of the causes producing insulinresistance. In this review article, I introduce importanceof body （interstitial） fluid pH in regulation of bodyfunction, evidence on abnormal regulation of bodyfluid pH in diabetes mellitus, and relationship betweenthe body fluid pH and insulin resistance. Further, thisreview proposes perspective therapies on the basis ofregulation of body fluid pH including propolis （honeybeeproduct） diet.
基金
Supported by Grants-in-Aid from Japan Society of the Promotion of Science,No.25670111
by Adaptable and Seamless Technology Transfer Program through Target-Driven RD Japan Science and Technology Agency(JST),No.2012-2013
by KIT-KPUM-KPU-KPh U Collaborative Research Program,No.2013-2014
by Salt Science Foundation(1235)and Cell Research Conference
