摘要
Despite the advances in the hematology field, blood transfusion-related iatrogenesis is still a major issue to be considered during such procedures due to blood antigenic incompatibility. This places pluripotent stem cells as a possible ally in the production of more suitable blood products. The present review article aims to provide a comprehensive summary of the state-of-theart concerning the differentiation of both embryonic stem cells and induced pluripotent stem cells to hematopoietic cell lines. Here, we review the most recently published protocols to achieve the production of blood cells for future application in hemotherapy, cancer therapy and basic research.
Despite the advances in the hematology field, bloodtransfusion-related iatrogenesis is still a major issueto be considered during such procedures due to bloodantigenic incompatibility. This places pluripotent stemcells as a possible ally in the production of more suitableblood products. The present review article aims toprovide a comprehensive summary of the state-of-theartconcerning the differentiation of both embryonic stemcells and induced pluripotent stem cells to hematopoieticcell lines. Here, we review the most recently publishedprotocols to achieve the production of blood cells forfuture application in hemotherapy, cancer therapy andbasic research.
