丝裂原活化蛋白激酶信号通路在骨关节炎发生中作用机制的研究进展

Role of Mitogen-activated Protein Kinases Signaling Pathway in Development of Osteoarthritis(review)

骨关节炎是发生在老年人群和运动员中的常见疾病。丝裂原活化蛋白激酶(MAPKs)是应力敏感分子,在骨关节炎发生和发展过程中具有重要作用,与软骨细胞凋亡和软骨细胞外基质降解存在密切联系。本文综述近年来骨关节炎和MAPKs家族蛋白相关的研究。

Osteoarthritis（OA） is a common disease among elders and athletes. Mitogen-activated protein kinases（MAPKs） are molecules of stress sensitivity which play a significant role in the occurrence and development of OA. MAPKs are closely related with chondrocyte apoptosis and cartilage degradation. This paper reviewed the related studies between OA and MAPKs.