血吸虫病患者血浆纤维连接素水平的变化

CHANGES OF THE LEVEL OF PLASMA FIBRONECTIN IN PATIENTS WITH SCHISTOSOMIASIS JAPONICA

检测了95例各期血吸虫病患者血浆纤维连接素(FN),水平,并对22例晚期血吸虫病(晚血)患者脾切除两周后的血浆 FN 水平进行对照观察,同时测定了17例急性血吸虫病(急血)患者外周血单核细胞体外诱生白细胞介素1(IL—1)的水平。急血患者血浆 FN 浓度显著升高并与 IL—1诱生水平明显呈正相关;慢性血吸虫病(慢血)患者血浆 FN 水平正常;晚血组的血浆 FN 浓度明显降低,脾切除后两周血浆 FN 水平显著升高,但仍然明显低于正常水平。提示急血和晚血患者的单核巨噬细胞系统功能分别被激活和受到损害,急血患者血浆 FN 水平的变化可能与 IL—1有关。

The detection of fibronectin (FN) in plasma of 95 patients with various stages of schistpsomiasis japoni- ca was conducted,and comparative observations on the level of plasma FN in 22 cases with advanced schis- tosomiasis japonica were carried out before and two weeks after splenectomy.The activity of IL—1 produced by peripheral blood monocytes in vitro in 17 patients with acute schistosomiasis japonica was determined si- multaneously.The concentrations of plasma FN were increased significantly,normal and reduced greatly in the cases with acute,chronic and advanced schistosomiasis japonica respectively.The induced level of IL—1 in patients with acute schistosomiasis japonica was significantly increased and positively correlated with the concentration of plasma FN.The level of plasma FN was greatly increased two weeks after splenectomy in patients with advanced schistosomiasis japonica,but still obviously lower than the normal level.The results suggest that the function of monocyte—phagocyte system is activated in patients with acute schistosomiasis japonica and damaged in cases with advanced schistosomiasis japonica.The increase of plasma FNin patients with acute schistosomiasis japonica may be related to IL—1.