摘要
目的检测β-链蛋白(β-catenin)、细胞因子4(Tcellfactor4,TCF-4)和带有血小板凝血酶敏感蛋白样模体的解整链蛋白金属蛋白酶-4(ADAMTS-4)在人不同退变程度软骨组织中的表达,并对其在骨关节炎的发生机制中的作用进行分析与探讨。方法以2010年1月至2014年8月就诊于本院的60例骨关节炎患者为研究对象,按照Mankin评分标准将其分为无退变组、轻中度退变组与重度退变组,分析不同组中β-catenin、TCF-4和ADAMTS-4的表达的差异性。结果三项检测物质在不同退变程度软骨组织中的表达存在显著性差异(P<0.05)。组内两两比较结果显示β-catenin、TCF-4和ADAMTS-4的表达水平在3组间的关系为无退变组<轻中度退变组<重度退变组,差异具统计学意义(P<0.05)。结论软骨组织中β-catenin、TCF-4及ADAMTS-4的高表达与OA的发生与发展密切有关。
Objective To detect the expression of β-catenin ,TCF -4 ,and ADAM TS -4 in cartilage tissue of different degeneration ,and analyze and discuss its role in the mechanism of osteoarthritis .Method 6 0 cases of patients with osteoarthritis from January 2 0 1 0 to August 2 0 1 4 in our hospital were selected and divided into no degeneration group ,mild to moderate degeneration group ,and severe degeneration group .Expression difference of β-catenin、TCF-4 ,ADAMTS -4 in different groups were analyzed .Result There were signifi-cant differences in the expression of cartilage tissue in different degeneration of the three different substances（ P〈0 .0 5 ） .Comparison between the groups showed that the expression level of β -catenin , TCF -4 , and ADAM TS-4 were as follows：no degeneration group 〈 mild to moderate degenerative Group 〈 severe degen-eration group . The difference was statistically significant （ P〈 0 .0 5 ） .Conclusion High expression of β -catenin ,TCF-4 ,and ADAM TS-4 in cartilage tissue is closely related with the occurance of OA .
出处
《内蒙古医学杂志》
2015年第2期151-153,共3页
Inner Mongolia Medical Journal
