尼可地尔对冠脉三支病变患者的疗效分析

Analysis of Nicorandil Efficacy in Patients with Coronary Artery Three-vessel Disease

目的观察尼可地尔对非血运重建的冠脉严重三支病变患者的疗效。方法选择冠状动脉造影证实冠脉严重三支病变的冠心病患者72例,随机分为尼可地尔治疗组(观察组n=35)和常规治疗组(对照组n=37),对照组患者视病情给予长效硝酸脂类、拜阿司匹林、氯吡格雷、他汀类、ACEI、钙离子拮抗剂等常规药物治疗;观察组在此基础上加用尼可地尔治疗。对比二组患者治疗前后心绞痛缓解情况及6 min步行实验改善情况。结果两组患者在治疗后心绞痛发作较前均有缓解,6 min步行实验距离较前提高,而尼可地尔治疗组更为明显,差异有统计学意义。结论在常规冠心病二级预防药物基础上加用尼可地尔对非血运重建的冠脉严重三支病变患者可显著改善心绞痛发作及提高活动耐量。

Objective Efficacy of nicorandil on non -coronary revascularization in patients with severe three-vessel disease .Methods 7 2 patients with Coronary angiography showed severe three branch disease was selected .The patients were randomly divided into nicorandil treatment group （observation group ,n=3 5 ） and conventional treatment group （control group ,n= 3 7 ） ,depending on the condition of patients in the control group given aspirin ,clopidogrel ,statins class ,ACEI ,calcium antagonists ,nitric acid and other conventional therapy ;observation group was based on the use of nicorandil treatment .Comparing two groups of patients be-fore and after treatment of angina and the 6 -minute walk test cases to improve the situation .Results Two groups of patients after treatment were compared with the previous relieve angina pectoris ,6 minutes walking distance from the previous experiment to improve ,further nicorandil treatment group is more obvious ,the dif-ference was statistically significant .Conclusion For non -coronary revascularization in patients with severe three-vessel disease ,in the conventional secondary prevention of coronary heart disease drugs based on the use of nicorandil curative efforts for nicorandil is obviously superior to improved angina and improve exercise toler-ance .