不同剂量阿托伐他汀治疗脑梗死疗效观察

Effect of atorvastatin on the prognosis of cerebral infarction and the changes of serum CRP

目的：观察不同剂量阿托伐他汀治疗脑梗死的疗效及血清CRP的变化。方法将纳入研究的131例患者按照使用药物剂量不同分为大剂量（40 mg）组69例和小剂量（10 mg）组62例。治疗4周后观察两组患者的临床疗效及CRP变化。结果大剂量组总有效率89．6％，小剂量组总有效率75．8％，两组总有效率差异有统计学意义（χ2＝4．61，P＜0．05）；两组治疗前后CRP差异均有统计学意义（t＝16．82、7．10，均P＜0．05）；治疗后，大剂量组与小剂量组CRP差异有统计学意义（ t＝9．64，P＜0．05）。结论大剂量阿托伐他汀治疗脑梗死可显著提高疗效，并可明显降低CRP水平，值得临床推广应用。

Objective To observe the effect of atorvastatin on the prognosis of cerebral infarction and the changes of serum CRP.Methods 131 cases of patients were divided into the high dose （40mg） group of 69 cases and small dose（10mg） group of 62 cases according to the use of drug doses .The efficiency and changes of CRP in two groups after 4 weeks of treatment was observed .Results Comparison of therapeutic results in patients after treat-ment,the total effective rate of the high dose group was 89.6%,the low dose group was 75.8%,the total efficiency of the two groups had significant difference （χ2 =4.61,P〈0.05）;CRP of the two groups after treatment had significant difference（t=16.82,7.10,all P〈0.05） with before treatment;CRP of the high dose group had significant difference with the low dose group（t=9.64,P〈0.05）.Conclusion High dose atorvastatin can significantly improve the prog-nosis of patients ,and can obviously reduce the CRP level ,which is worthy of clinical application .