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卵巢癌中CK2α蛋白表达及其与MMP-2关系 被引量：4

Expression of CK2α and its correlation with MMP-2 in ovarian tumors
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摘要 目的分析蛋白激酶CK2α在卵巢癌中表达意义及其与基质金属蛋白酶-2(MMP-2)的相关性。方法采用免疫组织化学SP法检测卵巢单纯性囊肿,卵巢良性瘤,卵巢癌组织中CK2α和MMP-2的表达情况,同时选取正常卵巢组织作为对照。结果 CK2α在卵巢癌组织中的表达明显高于单纯性囊肿和卵巢良性组织(P<0.01);CK2α蛋白表达水平与组织分级和临床分期有关(P<0.05);CK2α与MMP-2在卵巢癌中的表达有一定的相关性(r=0.543)。结论 CK2α在卵巢癌中的表达明显升高,其与MMP-2在卵巢癌中有一定的相关性可能与肿瘤的发生发展、浸润、转移有密切关系。 Objective To explore the expression and significance of casein kinase 2 α（CK2α） in ovarian tumors and to analyze the correlation betw een CK2α expression and matrix metalloproteinase 2（M MP-2）. Methods Surgical specimens in paraffin of simple ovarian cysts,benign ovarian tumor and ovarian cancer tissue,and normal ovarian tissue were collected. The expression levels of CK2α and MM P-2 were detected with immunohistochemical streptavidin-peroxidase conjugate（SP） method. Results The expression of CK2α protein in ovarian cancer was significantly higher than that in simple ovarian cysts and benign ovarian tumor（P〈 0. 01）. The expression of CK2α protein was correlated with histological type and clinical stage of the cancer（P〈0. 05）. Positive correlation was observed betw een the expression of CK2α and MM P-2（r = 0. 372）. Conclusion The upregulation of CK2α expression and its correlation with MM P-2 are related to the progression and metastasis of ovarian carcinoma.
作者 孙弋雅 郭琳 刘乙蒙 吴爽 刘超 肖建英
机构地区 辽宁医学院基础医学院生物化学与分子生物学教研室 锦州市食品药品检验所 辽宁医学院附属第一医院输血科 辽宁医学院基础医学院发育生物学教研室
出处 《中国公共卫生》 CAS CSCD 北大核心 2015年第4期470-472,共3页 Chinese Journal of Public Health
基金 辽宁省科技厅项目(2013225305)
关键词 卵巢癌CK2α MMP-2 免疫组化 ovarian cancer CK2α MMP-2 immunohistochemistry
分类号 R737.31 [医药卫生—肿瘤]
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参考文献11

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同被引文献46

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二级引证文献14

中国公共卫生
2015年 第4期

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