多模式镇痛对子宫切除术后疼痛及T淋巴细胞亚群的影响

The Effect of Multimodal Analgesia on Hysterectomy and the Distribution of T-lymphocytes

目的：观察多模式镇痛用于子宫切除术后镇痛的临床效果及对T淋巴细胞亚群的影响。方法60例ASAⅠ～Ⅱ级择期在腰硬联合麻醉下行子宫切除患者，将患者随机分为观察组和对照组，观察组应用帕瑞昔布钠复合舒芬太尼术后镇痛，对照组应用舒芬太尼术后镇痛。记录两组术后VAS评分及各个时间点抽取外周静脉血检测T淋巴细胞亚群含量。结果与T0相比较，两组T1、T2、T3、T4的CD3＋、CD4＋含量下降（P＜0.05），CD8＋含量升高（P＜0.05）；与对照组相比较，观察组T2、T3、T4的CD3＋、CD4＋含量升高（P＜0.05），CD8＋含量降低（P＜0.05）。结论多模式镇痛对于子宫切除患者镇痛效果显著，并可以保护T淋巴细胞功能从而减轻免疫抑制。

Objective To observe the effect of multimodal analgesia on hysterectomy and the distribution of T-lymphocytes. Methods 60 cases of abdominal hysterectomy patients received spinal combined with epidural anesthesia, were randomly divided into the observative group and the control group. Patients in the observaed group were used sufentanil postoperative analgesia combined with parecoxib sodium, patiens in the control group were used sufentanil postoperative analgesia only. Record postoperative VAS scores at each time point and drawn peripheral blood T lymphocyte subsets detected content. Results Compared with TO, the content of CD3＋. CD4＋ at T1, T2, T3, T4 decreased （P 〈 0.05）, however, the content of CD8 ＋ increased in both groups （P〈 0.05）. Compared with control group, the content ofCD3＋ ,CD4＋ at T2 , T3 , T4 increased （P〈0.05）, however, the content of CD8＋ decreased in the observed group （P〈0.05）. Conclusion Multimodal analgesia can alleviate the postoperative pain of hysterectomy patients, and protect the T lymphocyte function.