应用瞬时波强技术评价阻塞性呼吸睡眠暂停患者颈动脉弹性功能

Study of quantitative evaluation of carotid elasticity in patients with grading of OSAHS by Wave

目的应用瞬时波强(Wave Intensity,WI)技术检测阻塞性呼吸睡眠暂停综合征患者(OSAHS)患者颈动脉弹性功能,并探讨其临床意义。方法用WI技术依次检查呼吸睡眠暂综合征患者60例轻、中、重三组各20例及正常对照组20例;采集WI相关参数瞬时减速度波强(W2)、负向波面积(NA)、僵硬度(β)、压力应变弹性系数(Ep)、单点脉搏波传导速度(PWVβ)、脉搏波传导速度(PWVWI)、动脉顺应性(AC)、增大指数(AI)。结果与正常对照组比较,OSAHS 1轻度患者β、Ep、PWVβ、PWVWI、NA无明显增高(P>0.05)2组中度患者、3组重度患者两组β、Ep、PWVβ、PWVWI、NA明显增高(P<0.05),1级、2级组W2、AC、AI无明显差异(P>0.05),3级组W2、AI明显增高,AC明显降低。结论应用WI技术能检测阻塞性呼吸睡眠暂停综合征患者动脉血管内皮弹性随疾病进展发生的改变,有助于了解疾病的不同状态,便于判断病程及预后,对临床防治心血管并发症具有一定的指导意义。

Objective Using Wave Intensity（ WI） technique to evaluate the carotid elasticity quantitatively in patients with Obstructivesleeppapnea- hypopneasyndrome（ OSAHS）. Methods 60 patients of OSAHS and 20 normal subjects were examined in this study by WI respectively. With WI technique,we calculated the carotid elastic indexes ： instantaneous deceleration Wave Intensity（ W2）,Negative area（ NA）,stiffness parameter（ β）,strain elastic modulus（ Ep）,one- point pulse wave velocity（ PWVβ and PWVWI）,arterial compliance（ AC） and argumentation index（ AI）. Results Compared with grading OSAHS and the normal cases,the data of β,Ep,PWVβ,PWVWI,NA were all increased in grading OSAHS patients. In grade 1 and grade 2 groups of OSAHS,the data of W2,AI,AC had no significant different from the indexes of normal control. In grade 3 groups of OSAHS,the data of W2,AI were increased,AC were lower.Conclusion WI techinque can evaluate the arterial elasticity of the patients with OSAHS,it may be helpful understanding the progress and prognosis of diseases,and it may be useful for prevention and treatment of the complicated cardiovascular disease.