摘要
脑利钠肽作为内分泌激素主要通过调节水盐平衡维持机体内环境稳态,现已被广泛用于心血管疾病的临床诊断及判断预后,而近年来的研究表明其对代谢系统也有一定影响.脑利钠肽能通过加强脂质分解与脂肪动员作用改善脂代谢,而与糖代谢的关系尚存争议.多数研究显示其与血糖水平呈负相关,这主要与增加葡萄糖利用及扩血管作用有关.故脑利钠肽在减重、预防糖尿病及代谢综合征的发展中均有一定临床应用前景.
Brain natriuretic peptide（BNP） is a member of the endocrine system,and it maintains homeostasis of inner environment by regulating body fluid.BNP has been widely used to identify patients at high risk for cardiovascular disease and judge the prognosis.However recent studies have indicated that BNP also had an effect on metabolic system.BNP can ameliorate lipid metabolism via activating lipolysis and improving lipid mobilization,but the relationship between BNP and glucose metabolism is still controversial.Most studies suggest that BNP is negatively associated with glucose levels,which is mainly explained by increased usage of glucose and peripheral vasodilation of BNP.So there might be therapeutic potential of BNP in treatment of obesity,diabetes and metabolic syndrome.
出处
《国际内分泌代谢杂志》
2015年第2期103-105,共3页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目（81200594）
关键词
脑利钠肽
代谢综合征
脂代谢
糖尿病
肥胖
Brain natriuretic peptide
Metabolic syndrome
Lipid metabolism
Diabetes mellitus
Obesity
