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转录因子在上皮间质转化中分子机制研究进展 被引量：3

Recent progress of research on molecular mechanism of transcription factors in epithelial mesenchymal transition
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摘要 上皮细胞-间充质转化(epithelia-mesenchymal transition,EMT),是指上皮细胞通过特定程序转化为具有间质表型细胞的生物学过程,目前研究证实这种表型的转化与转录因子密不可分。与其他转录因子相比,转录因子SNAIL、TWIST、ZEB为促进EMT过程的主要转录因子,本文总结国内外与EMT相关研究并对转录因子及其在EMT过程中的分子机制加以综述。 The transdifferentiation of epithelial cells into motile mesenchymal cells was known as epithelial-mesenchymal transition （EMT）. This switch in cell behavior has been illustrated to be mediated and closely related by some key transcription factors, including SNAIL, zinc-finger E-box-binding （ZEB） and basic helix-loop-helix transcription factors （TWIST）. This article reviewed the research of recent progress of transcription factors the related mechanism of EMT.
作者 郭鹏 董栋栋 王进 许建发 冯和林
机构地区 河北医科大学第四医院骨科 河北医科大学第四医院泌尿外科
出处 《临床与病理杂志》 CAS 2015年第3期479-483,共5页 Journal of Clinical and Pathological Research
基金 河北省自然基金面上项目(H2015206314)~~
关键词 肿瘤 上皮-间质转化 转录因子 文献综述 cancer epithelial-mesenchymal transition transcription factors review
分类号 R730.2 [医药卫生—肿瘤]
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参考文献32

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二级参考文献30

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共引文献12

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二级引证文献12

临床与病理杂志
2015年 第3期

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