氟素制剂促进离体乳牙再矿化作用的比较研究

The effects of three fluoride-containing agents on the remineralization of deciduous teeth in vitro

目的 :比较 3种常见氟素制剂对乳牙体外矿化的促进作用 ,评估其防龋效果。方法 :36个乳牙 ,随机分为 4组 ,开窗 ,酸蚀。 1、2、3组分别涂布 10 0 g/L (NH4 ) 2 MoO2 F4 、380 g/LAg(NH3 ) 2 F、APF LaCl3 3min ,第 4组作对照 ,随后置入 5ml矿化液中。 4d后检测矿化液中Ca2 + 浓度 ,计算其变化并进行统计分析。结果 :同对照组相比 ,3种氟素制剂处理组再矿化液中Ca2 + 均显著减少 ,其中以APF LaCl3 组和 380 g/LAg(NH3 ) 2 F组减少最多 ,两组间无差异 ,但同 10 0g/L(NH4 ) 2 MoO2 F4 组差别显著。结论 :3种氟素制剂都可有效的促进乳牙体外再矿化 ,其中APF LaCl3 和 380 g/LAg (NH3 ) 2 F效果最佳 ,优于 10 0 g/L(NH4 ) 2 MoO2 F4 。

Objective: To compare the effects of three fluoride-containing agents on the remineralization of deciduous teeth in vitro. Methods: 36 deciduous teeth were randomly divided into four groups with 9 in each. The teeth were fenestrated on the labial middle surface and the rest parts of the teeth were covered with red nail polish.Every exposed area was etched,rinsed and puffed.Then the exposed areas were treated with 100 g/L(NH 4) 2MoO 2F 4(group ①) , 380 g/L Ag(NH 3) 2F (group ②) and APF-LaCl 3(group ③) for 3 minutes respectively, those in group④ were treated with deionized H 2O as the controls.Then,the teeth were placed into a bottle containing 5 ml remineralization solutions. 4 days later, the concentration of Ca 2+ in the remineralization solutions was measured. Results: The Ca 2+ concentrations (mmol/L) in the remineralization solution of group ①,②,③ and ④ were 0.338 9±0.116 5,0.570 0±0.145 5,0.517 8±0.084 8 and 0.120 4±0.046 8 respectively (P<0.01:①vs②,①vs③,①vs④,②vs④,③vs④;P>0.05:②vs③). Conclusion: The results indicate that all of the three fluoride-containing agents can promote the remineralization of deciduous teeth in vitro, and that both APF-LaCl 3 and 380 g/L Ag(NH 3) 2F are more effective than 100 g/L(NH 4) 2, MoO 2 F 4.