达泊西汀合成研究进展

Research Progress of Dapoxitine Synthetic Method

达泊西汀是是世界上第一个被批准用于治疗早泄的口服药,由于其具有一个手性中心,因此其合成有一定的难度。文章介绍了达泊西汀合成方法的研究进展,讨论了手性中心构筑的不同策略,总结了不同合成方法的优缺点。

Dapoxetinc is the world＇s first approved oral medication for the treatment of premature ejaculation. Because of having a chiral center, and therefore their synthesis have some difficulty. The paper introduced the research progress of dapoxetine synthetic method, discussed different strategies to build chiral center, and summarized the advantages and disadvantages of different synthetic methods.