醒脾养儿颗粒对厌食症患儿血清胃泌素、血浆胃动素及神经肽Y水平的影响

Effects of Xingpi Yang'er Granule on serum gastrin,plasma motilin,and neuropeptide Y levels in pediatric patients with anorexia

[目的]观察醒脾养儿颗粒对厌食症患儿血清胃泌素（GAS）、血浆胃动素（MOT）及血浆神经肽Y（NPY）水平的影响。[方法]选择2012年6月~2013年6月我院儿科就诊的110例厌食症患儿,随机分为治疗组和对照组,治疗组58例,对照组52例,治疗组采用醒脾养儿颗粒治疗,对照组采用胃蛋白酶合剂治疗,另选30名在我院体检健康的儿童作为健康组,观察病例组疗效及各组治疗前后GAS、MOT及NPY水平。[结果]治疗组和对照组总有效率分别为87.9%和65.4%,差异有统计学意义（P〈0.05）。与健康组比较,2组患儿治疗前GAS、MOT、NPY均降低（P〈0.05）。与本组治疗前比较,治疗组治疗后GAS、MOT、NPY明显升高（P〈0.05）,对照组治疗后MOT、NPY升高（P〈0.05）,GAS无明显变化。与对照组同期比较,治疗组治疗后GAS、MOT、NPY均较对照组高,差异均有统计学意义（P〈0.05）。[结论]厌食症患儿胃肠激素的含量有明显的改变,醒脾养儿颗粒对厌食症患儿GAS、MOT、NPY具有明显的调节作用。

[Objective]To observe the effects of Xingpi Yang＇er Granule（XYG）on serum gastrin（GAS）,plasma motilin（MOT）,and neuropeptide Y（NPY）in pediatric patients with anorexia[Methods]One hundren and ten pediatric patients with anorexia in our hospital from June 2012 to June 2013 were randomly assigned to two groups,58 cases in the treatment group and 52 cases in the control group.Treatment group was treated with XYG,while control group was treated with pepsin mixture.Besides,30 healthy children were recruited as the healthy control group.The clinical efficacy,changes of GAS,MOT,and NPY levels were observed.[Results]The total effective rate was 87.9%in the treatment group and 65.4%in the control group,the difference was statistically significant（P〈0.05）.Compared with healthy control group,the GAS,MOT and NPY levels decreased in the other two groups before the treatment（P〈0.05）.After the treatment,the GAS,MOT and NPY levels in the treatment group were obviously increased（P〈0.05）,the MOT and NPY levels were increased but the GAS level did not change in the control group（P〈0.05）.Compared with the control group at the same time point,GAS,MOT and NPY levels were increased in the treatment group,showing statistical significance（P〈0.05）.[Conclusion]The levels of GAS,MOT,and NPY obviously changed in pediatric patients with anorexia.XYG showed an obvious effect on regulating their GAS,MOT and NPY levels.