摘要
[目的]观察早期肠内营养添加L-谷氨酰胺呱仑酸钠对重症急性胰腺炎(SAP)的临床疗效。[方法]收集2013年3月~2014年8月我院收治的SAP患者74例,分为常规治疗对照组和L-谷氨酰胺呱仑酸钠观察组,每组37例。另取我院体检中心健康体检者40例作为正常对照。ELISA法检测IL-2、IL-6、TNF-α表达。[结果]对照组临床症状消失、血淀粉酶恢复以及住院时间分别为:(5.67±1.32)d、(6.43±1.61)d和(14.92±3.55)d,均显著高于观察组的(3.12±0.56)d、(4.24±1.05)d和(9.47±2.42)d(P〈0.05)。治疗前对照组和观察组IL-2、IL-6、TNF-α表达差异无统计学意义(P〉0.05),但均显著高于健康对照组(P〈0.01)。治疗后观察组对IL-2、IL-6、TNF-α的减低作用显著优于对照组(P〈0.01)。观察组的治疗有效率为94.6%显著优于对照组的78.4%(P〈0.05)。[结论]L-谷氨酰胺呱仑酸钠可以显著抑制SAP患者的炎症反应,临床疗效显著,值得临床推广使用。
[Objective]To detect the clinical efficacy of L-Glutamine and Sodium Gualenate on patients with severe acute pancreatitis(SAP).[Methods]Seventy-four SAP patients from our hospital were enrolled in this study.Patients were divided into:control group(n=37)and observation group(n=37).Forty healthy people were used as normal control.ELISA analysis was used to determine the expression of IL-2,IL-6,and TNF-α.[Results]The duration for the clinical signs to disappear,for blood amylase to recover to normal,and the average hospital stay in control group were 5.67±1.32 d,6.43±1.61 d,and 14.92±3.55 d,which were significantly higher than that of 3.12±0.56 d,4.24±1.05 d,and 9.47±2.42 din observation group(P〈0.05).Before treatment,the expression of IL-2,IL-6,and TNF-αwas not significantly different between control and observation group(P〉0.05),which was all significantly higher than that in healthy control group(P〈0.01).After treatment,the decrease of IL-2,IL-6,and TNF-αwas better in observation group than that in control group(P〈0.01).The clinical effective rate in observation was 94.6%,which was higher than78.4%in control group(P〈0.05).[Conclusion]L-Glutamine and Sodium Gualenate can inhibit inflammatory reaction in SAP patients and shows significant clinical effects,which is worthy of clinical application.
出处
《中国中西医结合消化杂志》
CAS
2015年第3期199-201,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
L-谷氨酰胺呱仑酸钠
重症急性胰腺炎
炎症反应
L-Glutamine and Sodium Gualenate
severe acute pancreatitis
inflammatory reaction