抗氧化系统对不同年龄患者冠状动脉病变程度的影响

Effect of antioxidant system on the coronary heart disease of different age patients

目的：探讨不同年龄患者过氧化氢酶（CAT）、超氧化物歧化酶（SOD）以及谷胱甘肽系统对冠状动脉（冠脉）病变程度的影响。方法：选取179例年龄49~90岁的心内科住院患者,分为〈60岁组（非老年组）77例,≥60岁组（老年组）102例。测定空腹血脂、血糖、CAT、SOD、还原型谷胱甘肽（GSH）、谷胱甘肽还原酶（GR）、谷胱甘肽过氧化物酶（GSH-Px）等,测量身高、体质量等指标。根据每例患者的冠状动脉造影结果,采用Gensini评分系统对每支血管病变程度进行定量评分。结果：老年组患者血浆CAT、SOD、GSH、GR和GSH-Px水平均低于非老年组患者（P〈0.05~P〈0.01）。校正年龄因素后,血浆CAT、SOD、GSH、GR和GSH-Px水平与Gensini积分仍呈显著负相关关系（P〈0.01）。多元线性回归分析显示,GSH-Px和CAT对Gensini积分的影响作用更大（P〈0.01）。结论：随着年龄增长,血浆CAT、SOD、GSH、GR和GSH-Px明显降低,与冠脉病变程度具有一定的负相关性,且CAT和GSH-Px对冠脉病变的影响作用更大。

Objective： To investigate the effects of catalase（ CAT）,superoxide dismutase（ SOD） and glutathione system on the coronary heart disease of different age patients. Methods： One hundred and seventy-nine 49 to 90 years old patients with coronary heart disease were divided into the non-senile group（ 77 cases,less than 60 years old） and senile group（ 102 cases,more than or equal to 60 years old）. The levels of fasting lipid,fasting glucose,CAT,SOD,GSH,GSH-Px and GR,height and weight in all cases were measured.The results of coronary arteriography of all cases were assessed using Gensini score system. Results： The serum levels of GSH,GSH-Px,GR,CAT and SOD in senile group were lower than those in non-senile group（ P〈 0. 05 to P〈 0. 01）. There was significantly negative correlation between the levels of GSH,GSH-Px,GR,CAT and SOD,and Gensini scores after righting age（ P 〈0. 01）. The results of multiple linear regression analysis showed that the effects of GSH-Px and CAT on Gensini scores were great. Conclusions： The levels of GSH,GSH-PX,GR,CAT and SOD significantly decrease with the growth of age,which is negative correlation with coronary artery disease. The effects of GSH-Px and CAT on coronary artery disease are great.