奥美拉唑、阿莫西林联合养胃舒治疗胃溃疡的临床疗效及安全性

Clinical Efficacy and Safety of Omeprazole, Amoxicillin Combined with Yangweishu for the Treatment of Gastric Ulcer

目的研究奥美拉唑、阿莫西林联合养胃舒在胃溃疡中的应用疗效及安全性。方法选择在我院治疗的胃溃疡患者74例作为研究对象,采用数字随机表法将患者随机分为两组各37例,对照组行奥美拉唑、阿莫西林治疗,观察组在此基础上给予养胃舒治疗,观察两组患者的临床疗效、并发症以及疾病复发率。结果观察组患者的治疗总有效率为97.30%,显著高于对照组的78.38%(P<0.05)。观察组治疗Hp根除率为81.08%,显著高于对照组的56.76%(P<0.05);随访1年,观察组Hp复发感染率为16.22%,显著低于对照组的43.24%(P<0.05)。两组患者治疗后并发症发生率无统计学差异(P>0.05)。结论采用奥美拉唑、阿莫西林联合养胃舒治疗胃溃疡,有利于提高Hp感染根除率,有效抑制胃溃疡创面的发展。

Objective To explore the clinical effect and safety of omeprazole, amoxicillin combined with Yangweishu for the treatment of gastric ulcer. Methods 74 patients with gastric ulcer were selected and randomly divided into two groups, with 37 cases in each group. The control group was treated with omeprazole and amoxicillin, while the observation group was treated with omeprazole, amoxicillin combined with Yangweishu. The clinical effect, complications, and recurrence rate were observed. Results The total effective rate of observation group was 97.30%, significantly higher than 78.38% of control group（P〈0.05）. The Hp eradication rate of observation group was 81.08%, significantly higher than 56.76% of control group（P〈0.05）. The recurrence rate of Hp infection of observation group was16.22%, significantly lower than 43.24% of control group（P〈0.05）. There was no statistically significant difference between two groups in the incidence of postoperative complications（P〉0.05）. Conclusions Omeprazole, amoxicillin combined with Yangweishu for the treatment of gastric ulcer can effectively improve the Hp eradication rate, and inhibit the development of gastric ulcer wounds.