髓源抑制细胞参与肿瘤免疫逃逸的研究进展

Research Progress of Myeloid-derived Suppressor Cells Involved in Tumor Immune Escape

肿瘤可以通过多种机制逃避机体的免疫识别,其中肿瘤诱导产生的髓源抑制细胞(MDSC)在肿瘤免疫逃逸中发挥着重要作用。MDSC是一群异质性细胞,来源于骨髓祖细胞和未成熟的髓细胞,它可以通过多种机制抑制机体的先天性和获得性抗肿瘤免疫,促进肿瘤发展。该文就MDSC的表面标志物、募集和活化、介导的免疫逃逸机制及当前靶向MDSC抗肿瘤治疗策略等的研究进展作一综述。

Tumors escape immune recognition by several mechanisms,and myeloid derived suppressor cells（ MDSCs） play a major role in tumor mediated immune evasion. MDSCs are a group of heterogeneous cell derived from myeloid progenitor cells and immature myeloid cells in bone marrow granulocytes. MDSCs promote tumors progression through inhibiting both innate and acquired immunity. Here is to make a review of the progress of MDSCs and its surface markers,the recruitment and activation,the MDSC-mediated immune escape mechanisms and antitumor treatment targeting at MDSC.