摘要
支气管哮喘的病理基础是慢性非特异性炎症,糖皮质激素是当前控制哮喘发作最有效的药物。然而,临床约有10%的哮喘经各种常规治疗效果不佳,并且通过增加激素剂量和延长激素使用疗程仍未有满意疗效,表现出激素抵抗现象,称为难治性哮喘。目前国内外难治性哮喘诊治水平普遍不高,是导致哮喘病死率、住院率及治疗费用升高的主要原因。因此,通过阐明糖皮质激素抵抗机制,从而发现潜在的能够逆转激素抵抗的方法对难治性哮喘临床治疗将具有重要意义。
Glucocorticoid therapy has proven to be remarkably successful in the treatment of chronic nonspecific inflammatory diseases,such as asthma. However,about 10% of patients with asthma show partial or complete resistance to the anti-inflammatory actions of glucocorticoids,limiting the effect of treatment,and the increase of dosage or prolongation of the treatment course do not receive satisfactory results,which is defined as intractable asthma. At present,the level of diagnosis and treatment of intractable asthma are generally not high,and is an important reason for high mortality,high hospitalization rates and increased treatment costs. Therefore,to clarify the mechanism of glucocorticoid resistance in order to identify potential methods to reverse hormone resistance in the clinical treatment of refractory asthma is of great significance.
出处
《医学综述》
2015年第6期1027-1030,共4页
Medical Recapitulate
关键词
支气管哮喘
难治性哮喘
糖皮质激素
激素抵抗
Bronchial asthma
Intractable asthma
Glucocorticoid
Steroid resistance
