抗心肌缺血药物的研究进展

Progress in Anti-ischemic Drugs Research

缺氧可引起组织严重损伤,常见的引起缺氧的疾病包括脑卒中、急性高山病、冠状动脉粥样硬化所导致的心肌梗死等。心肌缺血损伤是由于心肌细胞供氧不足而造成的心肌细胞坏死或功能受损;而缺血/再灌注损伤是血液中的氧与受损心肌细胞反应,形成的氧自由基对心肌细胞所造成的损伤。该文主要介绍近年来抗心肌缺血药物的研究进展及其抗心肌缺血的主要机制以及常用的缺氧和缺血药物研究模型。

Hypoxia can cause severe tissue damage. Common diseases related to hypoxia include stroke,acute mountain sickness and myocardial infarction caused by coronary atherosclerosis. Myocardial ischemia damage is myocardial cell necrosis or dysfunction caused by lack of oxygen and myocardial ischemia. When ischemia-reperfusion occurs,oxygen in blood enters the damaged myocardial cells,then biochemical reactions in the damaged myocardial cells produce oxygen free radicals which could induce more serious injury to the myocardial cells. Here introduces the research advances of anti-myocardial ischemia drugs,their mechanisms and the models of hypoxia and ischemia used in the drug research in recent years.