摘要
目的评价心型脂肪酸结合蛋白(H-FABP)、肌红蛋白(Mb)和心肌肌钙蛋白T(c Tn T)不同组合形式诊断急性心肌梗死(AMI)的效能。方法收集2011年10月至2013年9月来邯郸市中心医院就诊的AMI患者106例作为心肌梗死组,同期进行健康体检的健康者60例作为对照组,分别检测血清H-FABP、Mb及c Tn T的水平。比较三种指标不同组合形式诊断AMI的效率。结果H-FABP+c Tn T+Mb组合形式的诊断效能最高,H-FABP+c Tn T+Mb组合形式的受试者工作特征曲线下面积与H-FABP、c Tn T、Mb、H-FABP+c Tn T及H-FABP+Mb比较差异有统计学意义(P<0.05),与c Tn T+Mb组合形式比较差异无统计学意义(P>0.05),但是其曲线下面积仍高于c Tn T+Mb组合。结论 H-FABP+c Tn T+Mb组合形式诊断AMI的效能最高,这种组合形式与实验室信息管理系统联合能为AMI的诊断提供更直观和方便的参考价值。
Objective To evaluate the diagnosis efficiency of heart fatty acid binding protein（ H-FABP）,myoglobin（ Mb） and cardiac tropomin T（ c Tn T） as different combination types on diagnosis of acute myocardial infarction（ AMI）. Methods A total of 106 AMI patients admitted to the Handan Central Hospital from Oct. 2011 to Sep. 2013 were collected as myocardial infarction group,and another 60 healthy people during the same period were included as the control group. The levels of H-FABP,Mb and c Tn T were determined,and then the diagnosis effectiveness of the three indicators as different combination types was evaluated. Results The diagnosis effectiveness of H-FABP ＋ c Tn T ＋ Mb was the highest. The area under curve of H-FABP ＋ c Tn T ＋ Mb was significantly higher than that of H-FABP ＋ c Tn T,H-FABP ＋ Mb,H-FABP,c Tn T and Mb（ P〈0. 05）,and had no statistically significant difference from c Tn T ＋ Mb（ P〉0. 05）,however,the area under the curve was higher than c Tn T ＋ Mb. Conclusion The diagnosis effectiveness of H-FABP ＋ c Tn T ＋ Mb is the highest and its combination with the laboratory information management system can provide more direct and convenient references for clinical diagnosis of AMI.
出处
《医学综述》
2015年第6期1092-1094,共3页
Medical Recapitulate
