小分子物质在诱导性多能干细胞中的研究进展

Progress in the reprogramming of induced pluripotent stem cells with small molecules

诱导性多能干细胞可以分化成多种类型的细胞，为人类疾病模型建立，药物毒性筛选及自体细胞来源等多方面开辟了发展的前景。然而诱导性多能干细胞的重编程技术还存在安全性及低效率等诸多问题。小分子物质的方法被认为是改善诱导性多能干细胞过程的一种有前途的方法。目前越来越多的小分子物质已经确定可以维持干细胞的自我更新，为产生理想的重编程细胞提供了新的方法。

Induced pluripotent stem cells can differentiate into a variety of cell types, which promote the development of human disease model, drug toxicity screening and sources of autologous cells. However, there have been many problems in the induced pluripotent stem cells reprogramming, such as safety and low efficiency. Small molecules are considered as a promising method to improve the reprogramming processes of induced pluripotent stem cell, and more and more small molecules have been identified to maintain stem cell self-renew-al,providing a new approach to produce the desired reprogramming cells.