孤独症谱系障碍神经免疫机制的研究进展

Researches on neuroimmunological pathogenesis of autism spectrum disorder

孤独症是一组发生在婴幼儿时期广泛而严重的神经系统发育障碍性疾病,2013年5月颁布的美国精神疾病诊断与分类手册第五版将孤独症更名为孤独症谱系障碍（autism spectrum disorder,ASD）.该文综述近年来ASD神经免疫机制方面的异常,包括免疫因子、神经递质与抗脑组织抗体等.

Autism is a series of extensive and severe neuronal disorders.Autism has renamed autism spectrum disorder（ASD）in the United States of the Diagnosis and Classification Manual Fifth Edition in May,2013.Abnormal neuroimmunological pathogenesis research of ASD in recent years is reviewed in this paper.Studies have found that children with ASD have abnormal proinflammatory factor,neurotransmitter and the emergence of a brain protein antibody.