新生儿败血症临床检测指标的研究进展

Progress of clinical indicators in the diagnosis of neonatal sepsis

新生儿败血症起病隐匿,进展迅速,临床症状缺乏特异性,极易发生休克、多器官功能损伤等严重并发症,因此,早期诊断是降低败血症新生儿病死率及改善预后的关键.目前,有关新生儿败血症临床检测指标包括细菌培养、急性时相反应蛋白、细胞因子、细胞表面抗原及细菌基因检测等.该文将对上述指标在新生儿败血症的早期诊断、病情评估、治疗监测中的临床意义进行综述.

Neonatal sepsis progresses very fast,and its clinical signs are non-specific,and it can cause severe complications,such as shock,MODS.Therefore,early diagnosis is key to reduce mortality and improve prognosis.The clinical indicators in diagnosis of neonatal sepsis includ bacterial culture,peripheral hemogram,acute phase reaction proteins,cytokines,cell surface antigen and bacterial gene detection.This article reviews the clinical significance of these indicators in the early diagnosis,condition assessment,treatment monitoring of neonatal sepsis.