肝细胞癌循环肿瘤细胞标志物及检测方法研究进展

Progress for Biomarkers and Detection Methods of Circulating Tumor Cell of Hepatocellular Carcinoma

肝细胞癌(hepatocellular carcinoma,HCC)在中国是一种高发病率和高死亡率的恶性肿瘤。肿瘤切除、肝移植是治疗该病最有效的手段,但术后的高复发率和高转移率是影响患者预后的重要因素。外周血循环肿瘤细胞(circulating tumor cells,CTCs)是导致肝细胞癌术后复发和转移的必要因子。综述了CTCs的标记物——磷脂酰肌醇蛋白聚糖-3、转铁蛋白受体、甲胎蛋白、α-L岩藻糖苷酶、上皮细胞粘附因子、高尔基蛋白73和异常凝血酶原等,以及利用这些标记物检测CTCs的特异性和灵敏度,以期为肝细胞癌转移的早期检测、术后的复发、预后评估和选择治疗方案等提供依据。

Hepatocellular carcinoma （ HCC ） is one of the high incidence and mortality rates of the malignant tumors in our country.Tumor resection or liver transplantation is the most effective means for treatment the disease.However, the high recurrence and transfer rates after operation influence seriously the prognosis of the patients.Circulating tumor cells （ CTCs） in the peripheral blood is the important factor resulting in recurrence and metastasis of liver cancer after operation.In this paper, we reviewed the biomarkers of CTCs, e.g., glypican-3, transferrin receptor, alpha-fetoprotein, α-L-fucosidase, epithelial cell adhesion molecule, golgi protein, des-gamma-carboxy prothrombin, and the specificity and sensitivity for detection of CTCs using these biomarkers.The review was benefited for detecting the early cancer metastases, monitoring the recurrence, evaluating prognosis and choosing specific treatments for the patients with hepatocellular carcinoma.