骨科手术切口感染金黄色葡萄球菌的耐药性分析

Analysis on drug resistance of Staphylococcus aureus in orthopedic operative incision infection

目的了解金黄色葡萄球菌在骨科患者手术切口中的分布特征和耐药性,为骨科医生治疗及控制医院感染选择合理的抗菌药物提供依据。方法对2010年1月至2013年11月21 852例经手术治疗的骨科患者切口中分离的病原菌资料进行回顾性分析。结果共检出病原菌568株,感染率为2.6%,其中金黄色葡萄球菌134株(23.6%);耐甲氧西林金黄色葡萄球菌(MRSA)104株,均对万古霉素、利奈唑胺和奎诺普丁100.0%敏感。结论金黄色葡萄球菌是骨科手术切口感染的主要病原菌,及早发现并结合药敏试验,正确选用抗菌药物是治疗成功的关键。

Objective To understand the distribution characteristics and drug resistance of Staphylococcus aureus in the patients with orthopedic operative incision infection to provide the basis for selecting proper antibacterial drugs to treat and control the noso‐comial infection by the orthopedic doctors .Methods The data of the pathogens isolated from the operative incision in 21 852 ortho‐pedic patients treated by operation from January 2010 to December 2013 were performed the retrospective analysis .Results 568 strains of pathogenic bacteria were isolated .The infection rate was 2 .6% ,in which 134 strains （23 .6% ） were Staphylococcus au‐reus ,104 strains were methicillin‐resistant Staphylococcus aureus（MRSA） ,all of the isolates were sensitive to ancomycin ,linezolid and quinupristin .Conclusion Staphylococcus aureus is the main pathogens of the operative incision infection in the orthopedic de‐partment .Detection as early as possible and correctly using antibacterial drugs by combining with the drug susceptibility test results are the keys for successful therapy .