1294例女性高危型人乳头瘤病毒基因分型结果回顾性分析

Retrospective analysis of high risk human papillomavirus genotypes infection among 1 294 women

目的了解北京地区妇科门诊就诊女性高危型人乳头瘤病毒（HPV）的感染及其基因亚型分布情况,为该市今后防治人乳头瘤病毒感染和宫颈癌提供参考依据。方法回顾性分析2013年1月至2014年5月该院妇科门诊就诊的1 294例女性宫颈拭子的13种高危型HPV基因分型检测结果,比较不同基因型的流行病学特点。采用SPSS17.0对数据进行统计学分析。结果 1 294例妇科门诊就诊女性中,以58型、16型和52型HPV最为常见,检出率分别为10.5%、9.2%和8.2%。各年龄段就诊女性中,30~〈40岁的HPV感染率最高（39.9%）,其次为40~〈50岁、大于或等于60岁,差异无统计学意义（P〉0.05）。结论该地区妇科门诊就诊女性高危型HPV感染率较高,应加强HPV筛查力度,为今后HPV相关疾病的防治提供基础依据。

Objective To understand the prevalence and sub‐genotypes distribution situation of high risk human papillomavirus （HPV） infection in the gynecological outpatient department in Beijing area in order to provide the reference basis for the prevention and treatment of HPV infection and cervical cancer .Methods The detection results of 13 kinds of high risk HPV genotypes among 1 294 women in the gynecological outpatient department of this hospital from January 2013 to May 2014 were performed the retro‐spective analysis for comparing the epidemiological characteristics of different HPV genotypes .The SPSS17 .0 software was adopted to perform the statistical analysis .Results Among 1 294 detected women ,HPV‐58 ,HPV‐16 and HPV‐52 were most common ,the detection rates were 10 .5% ,9 .2% and 8 .2% respectively .Among various age groups ,the 30 - 〈 40 years group had the highest HPV detection rate（39 .9% ） ,followed by the 40 -〈50 years group and the ≥ 60 years group ,but the difference among them had no statistically significance （P〉0 .05） .Conclusion The women going to the local outpatient department have the higher prevalence of high risk HPV infection .The intensity of HPV screening should be strengthened in order to provide the fundamental basis for the prevention and treatment of HPV related diseases .