日平均气温对医院慢性阻塞性肺疾病急性加重患者住院人次的影响

Effect of daily mean temperature on hospital admissions of patients with acute exacerbation of chronic obstructive pulmonary disease

目的:探讨吉林省长春市不同季节日平均气温(DMT)与慢性阻塞性肺疾病(COPD)急性加重(AECOPD)患者住院人次的关系,阐明DMT对AECOPD的影响。方法:选择确诊并进行住院治疗的2 564例AECOPD患者的临床病历资料及同期气象因素资料,采用病例交叉设计研究分析不同季节气象因素与AECOPD的关联性。结果:在控制日平均相对湿度(DMRH)、日平均风速(DMWS)及日平均气压(DMAP)等气象因素的条件下,春、夏季DMT每升高1℃,AECOPD患者住院人次分别增加18.9%(OR=1.189,95%CI=1.152-1.228)和14.2%(OR=1.142,95%CI=1.074-1.214);秋季DMT每升高1℃,AECOPD患者住院人次降低9.7%(OR=0.903,95%CI=0.874-0.933);冬季DMT与AECOPD患者住院人次无关联(P>0.05)。结论:春、夏季DMT升高可能是AECOPD患者的危险因素;秋、冬季DMT升高是AECOPD患者的保护因素。

Objective To explore the correlation between the daily mean temperature（DMT）and the hospital admissions of the patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）in different seasons in Changchun City,and to clarify the effect of DMT on AECOPD.Methods The clinical data of2 564 AECOPD patients and meteorological variables in the same period were collected.A case-crossover study design was used to investigate the association between different meteorological variables and AECOPD in different seasons.Results Under the conditions of adjusting the influences of the daily mean relative humidity（DMRH）,daily mean wind speed（DMWS）,and daily mean atmospheric pressure（DMAP）,when the DMT was increased by1%,the hospital admissions of the patients with AECOPD in spring and summer were increased by 18.9%（OR=1.189,95%CI=1.152-1.228）and 14.2%（OR=1.142,95%CI=1.074-1.214）（P〈0.05）,and it was decreased by 9.7%（OR=0.903,95%CI=0.874-0.933）in autumn（P〈0.05）.But there was no significant association between the DMT and the hospital admissions of the patients with AECOPD in winter（P〉0.05）.Conclusion The increasing of DMT may be a risk factor of the patients with AECOPD in spring and summer;however,it may be a preventive factor in autumn and winter.