氧气驱动雾化吸入在支气管哮喘急性发作患者中的综合应用价值探讨

Research about the integrated value of oxygen drive aerosol inhalation for patients with acute exacerbation of bronchial asthma

目的:分析氧气驱动雾化吸入在支气管哮喘急性发作中的综合应用价值。方法:将180例来本院接受雾化吸入治疗的支气管哮喘急性发作患者随机分为两组,随机分为两组,对照组和观察组各90例。雾化吸入的药物均为沙丁胺醇和布地奈德,其中对照组采用超声雾化吸入法,观察组则采用氧气驱动雾化吸入法。比较两组间疗效及临床症状缓解时间差异,比较治疗前后两组间肺功能及血清炎症因子水平差异。结果:观察组临床控制率和治疗总有效率明显高于对照组,观察组发热、咳嗽、气喘、哮鸣音及肺部啰音等临床症状缓解时间明显短于对照组,差异均具有统计学意义(P<0.05);治疗后第3、7天,观察组最大呼气峰流速(PEF)、第1S用力呼气容量(FEV1)大于对照组,而肺泡-动脉氧分压差(PA-aDO2)和呼吸指数(RI)则明显高于对照组,差异具有统计学意义(P<0.05);观察组血清炎症因子白介素-4(IL-4)、白介素-6(IL-6)、白介素-17(IL-17)、肿瘤坏死因子(TNF-α)水平均低于对照组,差均异具有统计学意义(P<0.05)。结论:氧气驱动雾化吸入能更有效的改善支气管哮喘急性发作者的炎症状态和肺功能,相比于超声雾化吸入能促进哮喘急性发作症状更快更好的缓解。

Objective： To observe the value of oxygen drive aerosol inhalation for patients with acute exacerbation of bronchial asthma. Methods= 180 cases of patients with acute exacerbation of bronchial asthma in our hospital for inhalation ther- apy were randomly divided into control group and observation group, each group ha.d 90 cases,inhalation drugs both were al- buterol and budesonide, and patients in control group took ultrasonic atomizing inhalation, and those in observation group were treated by oxygen drive aerosol inhalation. Then the efficacy and time of clinical remission of two groups compared, and the pulmonary function and the serum levels of inflammatory cytokines of two groups before and after treatment were detected and compared. Results=The clinical management rate and the total effective rate of observation group were all significantly higher than control group, clinical remission time of fever, cough, shortness of breath, wheezing and pulmonary rates were all shorter than control group （P〈0.05）. 3, 7 days after treatment, the pulmonary function related indictors such as PEF, FEV1 of ob- servation group were all bigger than control group, while the PA-aDO2 and RI were higher than control group ;and the serum levels of inflammatory cytokines such as IL-4, IL-6, IL-17, TNF-αwere all significantly lower than control group （P all 〈0.05）. Conclusion：Compared to ultrasonic aerosol inhalation, oxygen drive aerosol inhalation can more effectively improve in- flammatory status and lung function for patients with acute exacerbation of bronchial asthma, and thus can relive symptoms of acute exacerbation of asthma symptoms more effectively.