摘要
目的了解11种呼吸道病原体Ig M抗体在慢性阻塞性肺疾病(COPD)阳性率及分布,指导临床合理用药。方法对2012年10月至2014年7月我院呼吸科收住的600例COPD患者的血清标本,应用呼吸道病原体抗体试剂检测11项病原体Ig M抗体,包括甲型流感病毒(IFA)、乙型流感病毒(IFB)、嗜肺军团菌(LP)、肺炎衣原体(CP)、肺炎支原体(MP)、呼吸道合胞病毒(RSV)、腺病毒(ADV)、副流感病毒1、2和3型(PIVS)以及柯萨基病毒A(COXA)、柯萨基病毒B(COXB)和埃可病毒(ECA),分析每种病原体及多重感染的阳性率。结果 COPD患者呼吸道病原体Ig M抗体阳性率为49.2%(295/600),各病原体中病毒的感染率较高,其中IFA占23.3%(140/600),RSV占6%(36/600),IFB占13%(78/600),ADV占5%(30/600),PIVS占4%(24/600);在非典型病原体中,CP占14%(84/600)MP占10%(60/600),LP占5%(30/600),COXA占2%(12/600),COXB2%(12/600),ECV2%(12/600);多重感染阳性率较单一阳性率高(p<0.05),其中合并2种病原体感染有18例,占阳性病例的14.5%,合并3种病原体的感染有8例,占阳性病例的2%。结论呼吸道病原体感染是COPD的重要诱因,其中呼吸道病毒感染是最常见的病原体,支原体、衣原体及嗜肺军团菌亦不能忽视,COPD患者易有多重病原体的混合感染。
OBJECTIVE To discuss the positive rate and distributionof the 11 respiratory pathogens of IgM antibody in patients with chronic obstructive pulmonary disease (COPD) , and guide the clinical rational drug use. METHODS The sera were collected from 600 chronic obstructive pulmonary disease patients and were subjected to simul- taneous detection of immunoglobin M of eleven pathogens, including Legionella pnettmophila ( LP), Mycoplasma pneumo- nia (MP), Coxiella burneti (COX), Ghlamydia pncumoniae (CP), adenovirus (ADV), respiratory syneytial virus (RSV), influenza A virus (IFA), influenza B virus B (IFB) and parainfluenza virus (PIV), Kirsaki A (COXA) vi- rus, Kirsakl virus B (COXB) and ECHO virus (ECV), via indirect immunofluorescence assay, then the positive rates of each pathogen and multiple infection were analyzed. RESULTS the positive rate was 49. 2% (295/600) in patients with COPD, high rate of vim IFA pathogens infection, which accounted for 23. 3% (140/600), RSV 6% (36/600), IFB 13% (78/600), ADV 5% (30/600), PIVS 4% (24/600). Among atypical pathogens, CP 14% (84/600), MP 10% (60/600), LP5% (30/600), COXA 2% (12/600), COXB 2% (12/600), ECV2% (12/600). There were 64 cases in Combined 2 pathogens infection, accounted for 28. 1% in total positive cases, and 41 cases in Combined 3 or more than 3 kinds of pathogens infection, accounted for 18. 4% in total positive case. CONCLUSION Respiratory pathogen infection was an important for COPD, the combined pathogens infection in patients with COPD often happened.
出处
《九江学院学报(自然科学版)》
CAS
2015年第1期76-78,87,共4页
Journal of Jiujiang University:Natural Science Edition
基金
江西省卫生厅科技基金(编号20143246)
江西省教育厅青年基金(编号GJJ12625)成果之一
关键词
慢性阻塞性肺疾病
呼吸道病原体
IG
M抗体
chronic obstructive pulmonary disease, respiratory pathogens, IgM antibody